Knee and hamstring complaints have prompted Les Bleus to put the Real Madrid striker on a personalized recovery plan ahead of Tuesday’s match as he has yet to return to full training.
Reports in France suggest a degree of mystery over Benzema’s exact issue and it is a big doubt for the game at Al-Wakrah.
Raphael Varane is another individual job who has been called up despite his own injury problem.
Didier Deschamps can no longer count on Christopher Nkunku, Presenl Kimpembe, Paul Pogba and N’Golo Kante for the duration of the World Cup after injuries.
Benzema’s absence could lead to a starting role for Olivier Giroud, although Deschamps has revealed plans to move away from his previous 3-4-1-2 formation that paired the forward with Kylian Mbappe.
Plans to play four at back will see brothers Theo and Lucas Hernandez compete for the left-back spot with Antoine Griezmann likely to be trusted to play behind Mbappe.
Arsenal defender William Saliba is in contention to form a defensive pairing in Varane’s possible absence, along with Jules Kounde, Dayot Upamecano or Ibrahima Konate.
Prediction France XI: you cry; Pavard, Saliba, Koundé, L. Hernández; Tchouameni, Camavinga; Dembélé, Griezmann, Eat; Mbappé. .