Seven teams have already booked their place in the quarter-finals, Charlton are the only non-Premier League side among them, and regardless of the result at the Etihad, it will be a team with a strong history in the competition to join those already in the box.
Liverpool are the defending champions after beating Chelsea in the final last season, although a much-changed Reds team required penalties to overcome third-tier Derby in the third round before the World Cup break.
city man meanwhile, they won the Carabao Cup for four years in a row before West Ham ended that run in the fourth round last season.
Neither team will be in top form so soon after the World Cup, but it’s almost always entertaining when these two heavyweight rivals meet.
Where to watch Manchester City vs Liverpool
Television channel: In the UK, the match will be televised live on Sky Sports Main Event and Football, with coverage starting at 7pm GMT before kick-off at 8pm.
Live broadcast: Fans can also watch the game live online via the Sky go app.
live blog: You can follow all the action of the day through Standard Sport Live Blog. .